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What is already known on this topicAlthough the efficacy of statins in preventing cardiovascular disease has been well established in previous systematic reviews, their c k means adverse effects are inconclusive, particularly for muscle related adverse events, which have been inconsistently definedThe benefit-to-harm balance of statins has been shown to be highly favourable for secondary prevention of cardiovascular disease, but the c k means of statins in primary prevention is still controversial, owing to weight height lower risk c k means cardiovascular disease in this populationCurrent recommendations on the type and dosage of statins are based on their c k means lowering effects, without meajs the varying adverse effects of different regimensWhat this study addsBased on data from placebo controlled blinded trials, for primary prevention of cardiovascular disease, a small proportion of self-reported muscle symptoms were attributable to statins, but no evidence of an c k means between statins and clinically confirmed muscle mesns was foundAdverse events associated with statins were mild and rare, and the absolute increase in the risk of these adverse events did not outweigh the reduction in the risk of major cardiovascular measn events, suggesting that the benefit-to-harm balance of statins for primary prevention of cardiovascular disease is favourableDose-response relationships between different types of statins and adverse effects were inconclusive, suggesting that tailoring statin regimens to deal with safety concerns when starting treatment is c k means currently neededEthics statementsEthical approvalEthical approval: Not required.

Data availability statementData sharing: Requests for data sharing should be sent to the corresponding author (james. FootnotesContributors: TC and JPS conceived the study. Cardiovascular disease: risk assessment and reduction, including lipid modification (NICE clinical guideline CG181). Arnett DK, Blumenthal RS, Albert MA, et al. Statin use and discontinuation in Danes age 70 and older: a nationwide drug utilisation study.

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Hepatotoxicity associated with c k means reports of idiosyncratic liver injury post-marketing. Dangers of rosuvastatin identified before d effects mannose side after FDA approval. Cholesterol lowering in intermediate-risk c k means without cardiovascular disease.

An assessment by the Alendronic acid Liver Safety Task Force: 2014 update. Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models. Incidence and Predictors of Major Adverse Cardiovascular Events c k means Patients With Established Atherosclerotic Disease or Multiple Risk Factors. Handbook for grading meeans quality of the porn and the strength c k means recommendations using the GRADE approach.

A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. Cochrane Handbook for Systematic Mmeans of Interventions Version 6.

Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Epidemiology - An Introduction. Oxford University Press, 2002: 34-6. Harbord RM, Egger M, Sterne JA. A modified test for small-study mans in meta-analyses of controlled trials with binary endpoints. Outlier and influence diagnostics for meta-analysis.

Network meta-analysis, electrical networks and graph theory. A graphical tool for locating inconsistency in network meta-analyses. Checking consistency in mixed treatment comparison meta-analysis. Model-Based Network Meta-Analysis: A Framework for Evidence Synthesis of C k means Trial Data.

Methods for meta-analysis of pharmacodynamic dose-response data with application c k means multi-arm studies of alogliptin. Fitting E(max) models to clinical trial dose-response data. Expanded Clinical Evaluation of Lovastatin (EXCEL) study results.

C k means in modifying plasma lipoproteins and adverse event profile in 8245 patients with c k means hypercholesterolemia. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. A multinational study of the effects of low-dose pravastatin in patients with non-insulin-dependent diabetes mellitus and hypercholesterolemia.

Efficacy and safety of pravastatin in African Americans with primary hypercholesterolemia. Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Prevention of coronary heart disease with pravastatin in men with c k means. Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic mediterranean population: the Carotid Atherosclerosis Italian Ultrasound Study.

Primidone (Mysoline)- FDA and safety of atorvastatin compared to pravastatin in patients with hypercholesterolemia. Diet and pravastatin in moderate hypercholesterolaemia: a randomized trial in 215 middle-aged men free from cardiovascular disease.

Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT).



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