Materials letters

Materials letters тему

Specific details of the RBC model and parameters can be found in refs. These studies have also yielded the retention rate of iRBCs by the spleen under different pathological states post-P. By monitoring surface area loss in P. Detailed analysis of the structure of the sinus wall in the spleen has also been performed (20), whereby materials letters dimensions of interendothelial slits were determined from observations in the transmission electron microscope.

Experiments showed that RBCs with abnormal properties were selectively retained by the microsphere filter with retention rates similar to those observed in the isolated perfused human spleen (16). Each particle materials letters DPD represents a cluster of atoms or molecules (24).

The DPD particles interact through pairwise forces: conservative, random, and dissipative. Materials letters particle in the RBC membrane becomes a DPD particle in simulations. The RBC is immersed into and filled with the DPD fluid. The RBC particles interact with the fluid particles through the DPD forces, and the motion of the RBC membrane materials letters fully coupled with the motion of the fluid.

Specific details of the DPD method implementation can be found in ref. When setting up the DPD model, reduced units materials letters implemented for the mass, length, and energy. In the following, the scaling relationships between model units and physical units are developed (26).

The endothelial cells are modeled by two slabs with cylindrical edges, and the annular fibers are modeled as slabs perpendicular to the endothelial cells. The bounce-back boundary condition (26) is enforced between the RBC membrane and the surfaces of the endothelial cells and the annular fibers. We considered 23,867 junction complexes in the RBC DPD model. The initial shear modulus for a healthy cell materials letters 5. The total cell surface area and cell volume are conserved during simulations.

This work is supported by National Institutes of Health (NIH) Grants U01HL114476 materials letters R01HL121386, a Swiss Platform for Advanced Scientific Computing grant, CSCS Grant s583, National Science Foundation XSEDE Project TG-MCB130124, and materials letters new DOE Collaboratory on Mathematics for Mesoscopic Modeling of Materials (CM4). Simulations were carried out at CSCS under Projects s583 and u4, Kraken materials letters Darter at the National Institute for Computational Sciences (NICS) under Project TG-MCB130124, and also at the Argonne Leadership Computing Facility (ALCF) through the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program at Argonne National Laboratory (ANL).

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Pivkin, Zhangli Peng, Materials letters E. Please see:Correction materials letters Pivkin et al. AbstractRed blood cells (RBCs) can be cleared from circulation when alterations in their size, shape, and deformability are detected. Results and DiscussionComputational Framework. The bounds predicted by the foregoing analysis can be compared with chemosis observations in the literature (23) as well as with gay page computational simulations.

Splenic Slit Clearance of RBCs Parasitized by P. We now consider healthy, ring- and trophozoite-stage RBCs invaded by P. Effects of Cell Volume. ConclusionsWe have developed computational simulations, coupled with a theoretical analysis, of the mechanics of RBC clearance materials letters the spleen. Ex Vivo and Synthetic Spleen Studies and Structural Materials letters. DPD Model and Scaling of Physical Units.

OpenUrlCrossRefPubMedPetroianu A (2011) The Spleen ford johnson Science Publishers, Hilversum, The Netherlands). Jandl JH, Greenberg MS, Yonemoto RH, Castle WB materials letters Clinical determination of materials letters sites of red cell sequestration in hemolytic anemias. OpenUrlCrossRefPubMedWaugh RE, et materials letters. OpenUrlCrossRefSafeukui I, et al.

Perrotta S, Gallagher PG, Mohandas N (2008) Hereditary spherocytosis. OpenUrlCrossRefPubMedPrendki V, et al. OpenUrlCrossRefPubMedDondorp AM, et al. OpenUrlCrossRefPubMedZaets SB, et materials letters. OpenUrlCrossRefPubMedCranston HA, et al.



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