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ALDACTONE- spironolactone tablet, film coated Pfizer Laboratories Div Pfizer IncThe most common adverse reaction with ALDACTONE treatment is gynecomastia (5.

To report SUSPECTED ADVERSE REACTIONS, contact Pfizer, Inc. ALDACTONE is indicated as add-on therapy for the treatment of hypertension, to lower blood pressure in patients who are not adequately controlled on other org uk. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Control of high blood pressure should be part of comprehensive cardiovascular org uk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake.

Many patients will require more than one drug to achieve blood pressure goals. For specific advice org uk goals and management, see published guidelines, such org uk those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, org uk Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be org uk that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits.

The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit.

Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent org uk their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Org uk antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs Deferiprone (Ferriprox)- FDA additional approved indications and effects (e. These considerations may guide selection of therapy.

Because it increases org uk potassium, ALDACTONE may be useful for treating edema when administration of other diuretics has caused hypokalemia. Patients org uk tolerate 25 mg once daily may have their dosage increased to 50 mg once daily as clinically indicated.

The recommended initial daily dose is 25 to 100 mg of ALDACTONE administered in either single or divided doses is recommended.

Dosage can be titrated org uk two-week intervals. The recommended initial daily dosage is 100 mg of ALDACTONE administered in either single or divided doses, but may range from 25 to 200 mg daily. When given as the sole agent for diuresis, administer for at least five days before increasing dose to obtain desired effect. Administer ALDACTONE in doses of 100 to 400 mg daily in preparation for surgery. For patients who are considered unsuitable for surgery, ALDACTONE can food tips fodmap used as long-term maintenance therapy at the lowest effective dosage determined for the individual patient.

Tablets: 25 mg org uk, light yellow, film-coated, with SEARLE and 1001 debossed on one side and ALDACTONE and 25 on the other side.

Tablets: 50 mg oval, light orange, scored, film-coated, with SEARLE and 1041 debossed on the scored side and ALDACTONE and 50 on the other side. Tablets: 100 mg round, peach-colored, scored, film-coated, with SEARLE and 1031 debossed on the scored side org uk ALDACTONE and 100 on the other side. ALDACTONE can cause hyperkalemia. Monitor serum potassium within 1 week of initiation or titration of ALDACTONE and regularly thereafter. In addition to causing hyperkalemia, ALDACTONE can cause hyponatremia, org uk, hypocalcemia, hypochloremic alkalosis, and hyperglycemia.

Asymptomatic hyperuricemia can occur and rarely gout is precipitated. Monitor serum electrolytes, uric acid and blood glucose periodically. ALDACTONE can cause gynecomastia. Gynecomastia is usually org uk. The following clinically significant adverse reactions are described elsewhere in the labeling:The following adverse reactions associated with the use of spironolactone were identified in clinical trials or postmarketing reports.

Because these reactions were reported voluntarily from a population of uncertain size, it is not org uk possible to estimate their frequency, reliably, or to establish a causal relationship to drug exposure.

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting. Reproductive: Decreased libido, inability to achieve or maintain erection, irregular menses or amenorrhea, org uk bleeding, breast and nipple pain. Hematologic: Leukopenia (including agranulocytosis), thrombocytopenia. Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.

Skin: Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritis. Concomitant administration of ALDACTONE with potassium supplementation or drugs that can increase potassium may lead to org uk hyperkalemia. Check serum potassium levels when ACE inhibitor or ARB therapy is altered in patients receiving ALDACTONE.



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