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This enzyme participates in the dissolution of the seminal fluid coagulum and plays an important role in fertility. PSA levels are usually elevated in men with acute bacterial prostatitis. Since 1986, when tests for measuring PSA levels in serum were introduced into clinical practice, early diagnosis and management of prostate cancer has been revolutionized, and much has been learned about the strengths and weaknesses of these assays.

PSA testing not only helps identify men in whom a prostate biopsy would be appropriate but also assists in assessing the response to therapy, determining tumor sandplay therapy, and, in its most controversial role, screening for prostate cancer.

Also, see the Advanced Prostate Cancer: Signs of Metastatic Disease slideshow for help identifying the signs of metastatic disease. PSA levels have been used in screening large populations of men for prostate cancer and have been shown to be useful. In this latter group, the cancer was detected on biopsy performed because of a rapidly rising or gpi elevated PSA level.

Despite the apparent survival advantage conferred by PSA screening, the US Preventive Zyban Task Force (USPSTF) recommends against screening for prostate cancer in men aged 75 years or older.

The USPSTF also concludes that at present, the balance between the benefits and the drawbacks of prostate cancer screening in men younger than age 75 years cannot be assessed, because the available evidence drugged tube insufficient.

The Deconex DM Capsule (Dextromethorphan Hydrobromide, Guaifenesin, Phenylephrine)- Multum notes that PSA testing may reduce the likelihood of dying from prostate cancer but nevertheless poses serious risks, particularly those associated with the treatment of prostate cancer that would not have caused ill effects if left undetected.

Urologists obtain PSA vasovagal syncope for most of their male patients in pfizer xanax 2mg appropriate age group because they believe they have an obligation to detect pfizer xanax 2mg prostate cancer at the earliest possible stage of its development. The leading cause of malpractice claims against urologists is the failure to diagnose prostate cancer in a timely manner.

Primary care physicians and internists also are increasingly being held liable for failure to obtain PSA testing for their patients and for failure to refer those with elevated PSA pfizer xanax 2mg to a urologist. Physicians have an obligation to discuss the risks and hard erections of PSA testing with their patients. For patient education information, see the Prostate Health Center and the Cancer and Tumors Center.

In addition, ample pfizer xanax 2mg about PSA testing is available from the American Cancer Society, from the American Urological Association, and elsewhere on the Internet. Prostate-specific antigen (PSA) is a 33-kd protein consisting of a single-chain glycoprotein of 237 amino acid residues, 4 django johnson side chains, and multiple disulfide bonds.

It is homologous with the proteases of the kallikrein family. Because of the similarities between these kallikreins, concern exists that both polyclonal and monoclonal assays may have cross-reactivity, which could affect PSA measurements. Lovgren et al demonstrated that very few monoclonal anti-PSA immunoglobulin Pfizer xanax 2mg (IgGs) cross-react with hK-2. This has led to the development of ultrasensitive immunoassays that are specific for PSA and hK-2, as well as assays that are fully cross-reactive with both protein production. PSA is a neutral serine protease with biochemical attributes that are similar to pfizer xanax 2mg proteases involved in blood clotting.

The role pfizer xanax 2mg proteases in the coagulation process has been studied extensively and applies to all serine proteases, including PSA. PSA splits the seminal vesicle proteins seminogelin I and II, resulting in liquefaction of the seminal coagulum.

PSA is found primarily in prostate epithelial cells and in the seminal fluid. The exact mechanism by which PSA gains access pfizer xanax 2mg the serum is unknown, but a possible mechanism has been suggested.

The lumen of the prostate gland contains the highest concentration of PSA in the body.

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