Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum

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Content is updated monthly with systematic literature reviews and conferences. Although access to this website is not restricted, Mutum information found here is intended for use by medical providers. Patients should address specific medical concerns with their physicians. Mechanism Potassium-Sparing Diuretic via aldosterone blockadeSpironolactone is a aldosterone competitive inhibitorActs at distal convoluted renal tubule Congestive Heart Failure Works synergistically with ACE Inhibitors in CHF ACE Inhibitors block Angiotensin II and alcohol antibiotics response is to increase AldosteroneSpironolactone blocks aldosterone escape III.

Gkycol Left-sided Congestive Heart FailureFirst line agent for NYHA Class III or IV Heart Failure, Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum conjunction with ACE Inhibitor and Beta BlockerMonitor for Hyperkalemia (esp. Contraindications Anuria Renal Insufficiency with Serum Creatinine over 2.

Drug Interactions Increased Serum Potassium (Hyperkalemia risk)Potassium SupplementationNSAIDsACE InhibitorTrimethoprim-Sulfamethoxazole SalicylatesDecrease Spironolactone effect Digoxin Increased Digoxin Stochastic processes risk via increased Digoxin half life Norepinephrine Decreases NorepinephrineVasopressor activity VI.

Dosing Congestive Heart Failure Start 12. Monitoring Serum Potassium Renal Function (Serum Creatinine) VIII. Pharmacokinetics Liver metabolism to active metabolite (canrenone) Primarily renal excretion Half-life: 14 to 16 hours (up to 24-36 hours) IX. Adverse Effects Gynecomastia (in men) Hyperkalemia Avoid excessive Dietary Potassium X.

This information is provided only to help medical providers and their patients salary therapist relative (MirwLAX). Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. Ontology: Spironolactone (C0037982) 350 (NCI) A Ciprofloxacin Hydrochloride Otic Suspension (Cipro HC Otic)- Multum 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.

Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.

Definition (MSH) A potassium sparing diuretic Polyethyllene acts by antagonism of aldosterone in the distal renal tubules. It is Mulltum mainly in the treatment of refractory edema (MjraLAX)- patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis.

Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. Definition (PDQ) A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.

Mechanism Indications Contraindications Drug Interactions Dosing Monitoring (MjraLAX)- Adverse Effects References Extra: Related Bing Images Extra: Related Studies Extra: Medication Costs Extra: UMLS Ontology Extra: Navigation Tree About 2021 Family Practice Notebook, LLC. Gov Survey of pharmacy drug pricing) A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum, and antiandrogen hc beer. A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules.

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Adults: 25 to 200 mg P. Adults: 50 to Polyethyene mg Popyethylene. Adults: Pklyethylene to 100 mg P. Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum of primary hyperaldosteronism. Adults: 400 mg P.

If hypokalemia and hypertension are corrected, a presumptive diagnosis of primary hyperaldosteronism is made. Adults: 50 to 200 mg P. Adults: 25 mg q. Adults: 50 mg b. Adults: 100 mg P. Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum Diuretic and potassium-sparing actions: Spironolactone competitively inhibits aldosterone effects on Glcyol distal renal tubules, increasing sodium and water excretion and decreasing potassium excretion.

Spironolactone is used to treat edema associated with excessive aldosterone secretion, such as that associated with hepatic cirrhosis, nephrotic syndrome, and heart failure. Antihypertensive action: The mechanism of action is unknown. Spironolactone may block the effect of aldosterone on arteriolar smooth muscle.

Metabolism: Rapidly and extensively metabolized to canrenone. Half-life of parent compound is 1 to 2 hours. Contraindications and precautions Contraindicated in patients with anuria, acute or progressive renal insufficiency, or hyperkalemia and in those receiving amiloride or triamterene.

ACE inhibitors, potassium supplements, potassium-containing drugs such as parenteral penicillin Polyethyene Increases risk of hyperkalemia when administered with these drugs.

Use together cautiously, (MirzLAX)- in patients with renal impairment. Anesthetics, norepinephrine: Reduces response to these drugs. Antihypertensives: May potentiate hypotensive effects. May be used to therapeutic advantage. Aspirin: May slightly decrease response to spironolactone. Watch for diminished effect.

Cardiac glycosides: Increases serum digoxin levels and subsequent toxicity. Potassium-sparing diuretics: Increases risk of hyperkalemia. Licorice: May block antiulcer and aldosterone-like effects of herb. Potassium-containing salt Polyethylene Glycol 3350 - OTC (MiraLAX)- Multum, potassium-rich foods (such as citrus fruit and tomatoes): Increases risk of hyperkalemia. Adverse reactionsCNS: headache, drowsiness, lethargy, confusion, ataxia. GI: diarrhea, gastric bleeding, ulceration, cramping, gastritis, vomiting.

GU: inability to maintain erection, menstrual disturbances in women. Metabolic: hyperkalemia, dehydration, hyponatremia, metabolic acidosis.

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